All-Natural, No Sugars
ATP Activate: Athlete’s Formulation relies on natural ingredients, not ephedra or artificial stimulants, to help maximize exercise performance. Furthermore, it provides only five grams of carbohydrates and zero sugars. By using natural flavors and stevia in place of sugar and other carbohydrates, the typical “sugar high” that is associated with many energy drinks can be avoided. Equally important, ATP Activate: Athlete’s Formulation contains no artificial colors.*
Oral supplementation of ATP (adenosine triphosphate) combined with resistance training has demonstrated ergogenic benefits. Peak ATP is a patented form of ATP disodium that has been shown in human studies to enhance muscular growth, power, and strength while improving recovery. Proposed mechanisms of action include increased muscular excitability, improved blood flow, and increased anabolic signaling.[1-4] As a result of these effects, Peak ATP helps athletes push themselves to greater levels of performance.*
Peak ATP supplementation (400 mg/d for 15 days) has been shown to increase post-exercise ATP levels and athletic performance following repeated sprint bouts. Lowery et al studied the effects of Peak ATP on blood flow in 12 college-aged, resistance-trained men. Participants were given 400 mg of Peak ATP daily for one week 30 minutes prior to an acute bout of arm exercise. Data demonstrated significant increases in vasodilation and blood flow at both zero and three minutes post-exercise. In a double-blind, placebo-controlled, crossover study, 400 mg of Peak ATP for 15 days “tended to reduce muscle fatigue while improving muscle low-peak torque through sets of exhaustive exercise.” In a double-blind placebo-controlled study, resistance-trained participants taking Peak ATP over 12 weeks experienced several benefits over placebo: increased strength (147%), increased power (30%), increased lean body mass (100%), and increased muscle thickness (96%). Additionally, body fat decreased in the supplemented group. Data also suggests that Peak ATP helped prevent performance declines seen in overreaching.*
Creapure® Creatine Monohydrate
Creatine supplementation increases the amount of creatine in muscle tissue, heightens energy production, decreases muscle fatigue, and reduces lactic acid output. Significant improvements in body mass, fat-free body mass, oxygen uptake, sprint performance, weightlifting volumes, and overall exercise performance following creatine supplementation have been demonstrated.[7-9] In ATP Activate: Athlete’s Formulation, a compounding effect of several ingredients is expected. In fact, the combinatory effects of caffeine, creatine, and amino acids has produced improvements in time to exhaustion (TTE) and peak velocity (PV) in humans.*
Creapure is premium, 100% pure creatine monohydrate that has been used with confidence for over 20 years. The Creapure brand is recognized for careful selection of raw materials, patented high-performance technology, sophisticated process engineering under GMP conditions, and precise chemical analysis to ensure consistency and purity.
Purenergy is an innovative patent-protected ingredient that combines caffeine with pTeroPure® pterostilbene—a highly bioavailable analog of resveratrol—to form a unique co-crystal structure. It appears that this unique structure affects the way the body utilizes caffeine. As such, it may offer significant advantages over caffeine alone. In a rat study (n=6), the half-life of caffeine from Purenergy was eight hours, while that of ordinary caffeine was just three hours. In a preliminary, four-week, single-blind, crossover human study (n=12) that compared 232 mg of Purenergy (providing 99.76 mg of caffeine) to 100 mg of ordinary caffeine, the absorption of caffeine from Purenergy was approximately 30% slower and Purenergy delivered 30% more caffeine to the bloodstream. Furthermore, at six hours, 51% more caffeine from Purenergy was detected in serum compared to ordinary caffeine.*[12,13]
These data suggest that the effects of caffeine from Purenergy may last longer than the effects from ordinary caffeine and point to a potential for reducing total caffeine intake. Additionally, the extended half-life and slower absorption rate of caffeine from Purenergy may produce a more moderated and gradual finish, thereby preventing the “crash” associated with regular caffeinated energy products. While the results of these studies are promising, larger studies are needed to validate the findings and determine if these findings translate into a lengthened energy effect.*
Herbs and Amino Acids
ATP Activate: Athlete’s Formulation combines Purenergy in a proprietary blend with various herbs and amino acids, including green tea extract, coffee fruit extract, taurine, and L-arginine alpha-ketoglutarate. This proprietary blend is designed to complement the activities of Purenergy. Furthermore, some of these individual ingredients taken in high doses have roles in mitochondrial biogenesis and are known to have a positive influence on exercise performance.*[14-16]
Electrolytes and Antioxidants
Electrolytes—including sodium, potassium, and magnesium— are important for energy production, nerve transmission, muscle contractions, pH balance, fluid balance, and more. Conditions that promote excessive sweating and increased metabolic activity can require replacement of these important minerals and increase the need for antioxidants. ATP Activate: Athlete’s Formulation provides 130 mg of sodium, 280 mg of potassium, and 150 mg of magnesium in each serving. To support protection from free radicals, ATP Activate: Athlete’s Formulation provides 500 mg of vitamin C in the form of four mineral ascorbates, as well as natural vitamin E, selenium, green tea extract, and s-acetyl-L-glutathione (SAG). SAG is an orally stable glutathione that has been shown to cross the membrane of the mitochondria, which increases the organelle’s activity and helps minimize reactive oxygen species.*
The B vitamins provided in ATP Activate: Athlete’s Formulation are in their activated forms to optimize bioavailability and utilization. As essential parts of coenzymes, these water-soluble nutrients are integral to the complex biochemical processes that convert food to glucose and ATP—the energy used by cells. Vitamin B12 also works closely with folate to help make red blood cells and facilitate the work of iron in the body. Iron helps carry oxygen to all cells, including muscle cells, for use in the generation of energy.*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
- Rathmacher JA, Fuller JC Jr, Baier SM, et al. Adenosine-5’-triphosphate (ATP) supplementation improves low peak muscle torque and torque fatigue during repeated high intensity exercise sets. J Int Soc Sports Nutr. 2012 Oct 9;9(1):48. [PMID: 23046855]
- Jäger R, Roberts MD, Lowery RP, et al. Oral adenosine-5’-triphosphate (ATP) administration increases blood flow following exercise in animals and humans. J Int Soc Sports Nutr. 2014 Jun 13;11:28. [PMID: 25006331]
- Wilson JM, Joy JM, Lowery RP, et al. Effects of oral adenosine-5’-triphosphate supplementation on athletic performance, skeletal muscle hypertrophy and recovery in resistance-trained men. Nutr Metab (Lond). 2013 Sep 22;10(1):57. [PMID: 24330670]
- Kichenin K, Decollogne S, Angignard J, et al. Cardiovascular and pulmonary response to oral administration of ATP in rabbits. J Appl Physiol (1985). 2000 Jun;88(6):1962-8. [PMID: 10846006]
- Rauch J, Lowery RP, Silva J, et al. The oral bioavailability of ATP following an intense sprinting protocol. In: National Strength and Conditioning Association 2014 Annual Meeting, Las Vegas, NV. J Strength Cond Res. 2014;28(suppl 2):S53-S54. http://journals.lww.com/nsca-jscr/Fulltext/2014/12001/NSCA_2014_Annual_Meeting.1.aspx. Accessed September 29, 2015.
- Lowery R, Roberts M, Booth F, et al. Oral ATP administration improves blood flow responses to exercise in both animal and human training models. In: Proceedings of the Tenth International Society of Sports Nutrition (ISSN) Conference and Expo, Colorado Springs, CO. J Int Soc Sports Nutr. 2013;10(suppl 1):P16. http://www.jissn.com/ content/10/S1/P16. Accessed September 29, 2015.
- Smith RN, Agharkar AS, Gonzales EB. A review of creatine supplementation in age-related diseases: more than a supplement for athletes. F1000Res. 2014 Sep 15;3:222. [PMID: 25664170]
- Aguiar AF, Januário RS, Junior RP, et al. Long-term creatine supplementation improves muscular performance during resistance training in older women. Eur J Appl Physiol. 2013 Apr;113(4):987-96. [PMID: 23053133]
- Bemben MG, Lamont HS. Creatine supplementation and exercise performance: recent findings. Sports Med. 2005;35(2):107-25. [PMID: 15707376]
- Fukuda DH, Smith AE, Kendall KL, et al. The possible combinatory effects of acute consumption of caffeine, creatine, and amino acids on the improvement of anaerobic running performance in humans. Nutr Res. 2010 Sep;30(9):607-14. [PMID: 20934602]
- Single-dose comparative pharmacokinetic study of pterostilbene, caffeine and combination of pterostilbene caffeine co-crystal in SD rats by oral route. Study report. Study No: VLL/0912/NG/D033; Version No.: 1.0. Genome Valley, Hyderabad, India: Vimta Labs Limited; November 2012:1-25. [on file]
- A crossover, clinical evaluation to determine the relative bioavailability, pharmacokinetics and safety of PURENERGYTM and pTeroPure® in healthy adult males. PK study summary. Miami, FL/Irvine, CA: Miami Research Associates/ChromaDex Inc.; 2013:1-34. [on file]
- PurenergyTM: A novel next-generation caffeine alternative. Irvine, CA: ChromaDex Inc.; September 10, 2014:1-5. [on file]
- Campbell B, Roberts M, Kerksick C, et al. Pharmacokinetics, safety, and effects on exercise performance of L-arginine alpha-ketoglutarate in trained adult men. Nutrition. 2006 Sep;22(9):872-81. [PMID: 16928472]
- Flôres MF, Martins A, Schimidt HL, et al. Effects of green tea and physical exercise on memory impairments associated with aging. Neurochem Int. 2014 Sep 6. [PMID: 25195719]
- Pandareesh MD, Anand T. Ergogenic effect of dietary L-carnitine and fat supplementation against exercise induced physical fatigue in Wistar rats. J Physiol Biochem. 2013 Dec;69(4):799-809. [PMID: 23661316]